Genome-Based Risk Prediction for Early Stage Breast Cancer
Cet article passe en revue les travaux récents sur l'intérêt des tests à base de mesures d'expression de gènes pour la prise en charge des patientes atteintes d'un cancer du sein de stade précoce
Tests to better characterize tumor genomic architecture are quickly becoming a standard of care in oncology. For breast cancer, the use of gene expression assays for early stage disease is already common practice. These tests have found a place in risk stratifying the heterogeneous group of stage I–II breast cancers for recurrence, for predicting chemotherapy response, and for predicting breast cancer-related mortality. In the last 5 years, more assays have become available to the practicing oncologist. Given the rapidity with which this field has evolved, it is prudent to review the tests, their indications, and the studies from which they have been validated. We present a comprehensive review of the available gene expression assays for early stage breast cancer. We review data for several individual tests and comparative studies looking at risk prediction and cost-effectiveness.
The Oncologist , résumé, 2014