No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk
Menée en Europe auprès de 9 006 cas et 9 503 témoins, cette étude évalue l'effet de polymorphismes à simple nucléotide de gènes impliqués dans des voies de signalisation liées au calcium, et précédemment identifiés dans des études d'association sur le génome entier, sur l'association entre consommation de calcium et risque de cancer colorectal
Background: Calcium intake may reduce risk of colorectal cancer (CRC), but the mechanisms remain unclear. Studies of interaction between calcium intake and single nucleotide polymorphisms (SNPs) in calcium-related pathways have yielded inconsistent results. Methods: To identify gene-calcium interactions, we tested interactions between ~2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental sources) in 9,006 CRC cases and 9,503 controls of European ancestry. To test for multiplicative interactions, we used multivariable logistic regression and defined statistical significance using the conventional genome-wide α=5E-08. Results: After accounting for multiple comparisons, there were no statistically significant SNP-interactions with total, dietary, or supplemental calcium intake. Conclusions: We found no evidence of SNP-interactions with calcium intake for CRC risk in a large population of 18,509 individuals. Impact: These results suggest that in genome-wide analysis common genetic variants do not strongly modify the association between calcium intake and CRC in European populations.