Prevalence, Incidence, Clearance and Associated Factors of Genital Human papillomavirus Infection among Men: a population-based cohort study in rural China
Menée en Chine auprès de 1 286 hommes âgés de 25 à 65 ans (durée médiane de suivi : 31,8 mois), cette étude de cohorte analyse l'incidence et la prévalence d'une infection génitale par le papillomavirus huamin ainsi que les facteurs associés
Background:The natural history of Human papillomavirus (HPV) infection in men on a population base has rarely been studied in general, particularly among Chinese men. Methods:1286 men aged 25-65 years from rural China were enrolled during 2009-2010 and their genital HPV infection status were assessed bi-annually for up to 7 visits using PCR and sequencing method. Prevalence analysis was performed among men with at least one valid HPV result (N=1279) and men with at least two consecutive HPV results (N=1059) were included in incidence and clearance analyses (median follow-up time: 31.8 months; interquartile range: 15.4-37.9 months). Results:The prevalence and incidence of any HPV type, oncogenic and non-oncogenic HPV were 17.8%, 6.4%, 12.4% and 14.6, 4.9, 10.8/1000 person months, respectively. The median duration of infection with any HPV type, oncogenic and non-oncogenic HPV was 11.5, 6.8 and 11.5 months, respectively. The number of lifetime sexual partner was consistently associated with increased risk of prevalent and incident infection of HPV. Men aged 25-50 years had a higher incidence and longer duration of HPV infection than older men (51-65 years). Conclusions:This epidemiological investigation provide basic information of genital HPV infection among Chinese male population. Impact:These data are crucial for the consideration of primary strategies against HPV-related carcinoma in Chinese male and female population.