Prophylactic cranial irradiation improved the overall survival of patients with surgically resected small cell lung cancer, but not for stage I disease
Menée à partir de données portant sur 193 patients atteints d'un cancer du poumon à petites cellules traité par résection complète entre 2003 et 2009, cette étude chinoise évalue, du point de vue des taux de survie globale à 2 et 5 ans, l'intérêt d'une radiothérapie crânienne prophylactique
Objectives : We conducted a retrospective study to evaluate the role of prophylactic cranial irradiation (PCI) on patients with surgically resected small cell lung cancer (SCLC). Patients and Methods : Between January 2003 and December 2009, the records of completely resected patients who were diagnosed with SCLC and definitive pTNM stage on the basis of histological proof were reviewed. According to the therapy modality, patients were allocated to PCI group and non-PCI group. Results : A total of 193 patients were finally included, 67 patients in PCI group and 126 in non-PCI group. The OS rates at 2-year and 5-year in PCI group were 92.5%, and 54.9%, respectively, and those of non-PCI were 63.2% and 47.8%, respectively (p = 0.005). The BMFS rate at 2-year and 5-year in PCI group were significantly better than those of non-PCI group (96.8%, 76.6% and 79.4%, 75.5%, respectively, p = 0.014). But PCI could not confer survival benefit in the patients with p-stage I. Multivariate analysis revealed that PCI (HR = 2.339; p = 0.001) was an independent prognostic factor of the overall survival. Conclusions : PCI could improve the OS of patients with surgically resected SCLC, but not for p-stage I patients.