Applying Synthetic Lethality for the Selective Targeting of Cancer
Cet article passe en revue les perspectives offertes par l'application du principe de létalité synthétique pour le développement de thérapies ciblées des cancers
Synthetic lethality refers to the requirement that two defects be present for cell death to occur. When an agent damages DNA, its effects on the cell can be amplified if the efforts of the cell to repair the damage are inhibited. Clinical application of this idea is just beginning.