Hippocampal-Avoidance Whole-Brain Radiation Therapy: A New Standard for Patients With Brain Metastases?
Mené sur 113 patients présentant des métastases cérébrales et traités entre 2011 et 2012, cet essai multicentrique de phase II évalue, du point de vue de la préservation de la mémoire et de la qualité de vie, l'intérêt d'épargner la zone de l'hippocampe comportant les cellules souches neuronales lors d'une radiothérapie du cerveau entier
The use of whole-brain radiation therapy (WBRT) for brain metastases was first described in the 1950s. Since that time, WBRT has long been considered the treatment of choice, given its wide availability, ease of delivery, and effectiveness in providing palliation for many patients. Numerous phase III trials have also validated its benefit in improving neurologic signs and symptoms for many patients, with median survival times ranging from 3 to 6 months...
Journal of Clinical Oncology , éditorial en libre accès, 2014