Non-coding RNAs as biomarkers for metastatic prostate cancer
Menée à partir d'échantillons tumoraux prélevés sur 545 patients atteints d'un cancer localisé de la prostate traité par prostatectomie radicale, puis validée sur 463 autres patients, cette étude multicentrique identifie un ARN non codant issu de la transcription du locus SChLAP1 (second chromosome locus associated with prostate-1) en association avec la progression métastatique de la maladie
At present, a surprisingly small number of protein-coding genes—conventionally cited as fewer than 25 000 1 —constitute elements of the functional human genome. A more recent estimate suggests that up to 70% of the human genome is transcribed into RNA, 2 which has ignited debate as to whether transcription of non-coding RNA represents true functional biology. Evidence suggests that non-coding RNAs, particularly long non-coding RNAs (lncRNAs), have essential roles in tumorigenesis, 3 and particularly c ...
The Lancet Oncology , commentaire, 2013