Late side-effects after curative intent radiotherapy: identification of hypersensitive patients for personalized strategy
Cet article fait le point sur les techniques permettant d'identifier les patients présentant une hypersensibilité aux rayonnements ionisants
Radiation therapy undeniably enhances local control and thus improves overall survival in cancer patients. However, some long-term cancer survivors (less than 10%) develop severe late radio-induced toxicities altering their quality of life. Therefore, there is a need to identify patients who are sensitive to those toxicities and who could benefit from adapted care. In this review, we address all available techniques aiming to detect patients’ hyper-radiosensitivity and present the scientific rationales these techniques are based on.
Critical Reviews in Oncology/Hematology , résumé, 2013