Controlling COR Competence: BCL-6 Regulates Neurogenesis and Tumor Suppression
Menée in vitro et in vivo, cette étude met en évidence des mécanismes par lesquels, en régulant la signalisation Sonic Hedgehog, la protéine BCL6 exerce une fonction de suppresseur de tumeurs dans les médulloblastomes
In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus controlling a pathway that is aberrantly activated in medulloblastoma.
Cancer Cell , commentaire, 2013