Immune-related conditions and acute leukemia in children with Down syndrome: A Children's Oncology Group report
Menée aux Etats-Unis par questionnaire auprès de 331 mères d'enfants atteints de trisomie 21, cette étude évalue l'association entre des conditions liées au système immunitaire de l'enfant (asthme, eczéma, allergies, hypothyroïdie) ou à un diabète et le risque de leucémie aiguë
Background: Children with Down syndrome (DS) have unique immune profiles and increased leukemia susceptibility. Methods: Mothers of 158 children with DS diagnosed with acute leukemia at 0-19 years in 1997-2002 and 173 children with DS but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression. Results: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (odds ratio=9.23, 95% confidence interval: 2.33-36.59), however most instances occurred concurrent with or after the leukemia diagnosis. Conclusions and Impact: Children with DS who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.