Low-dose aspirin use and the risk of ovarian cancer in Denmark
Menée au Danemark sur 4 103 patientes atteintes d'un cancer de l'ovaire diagnostiqué entre 2000 et 2011 et sur 58 706 témoins (âge : 30 à 84 ans), cette étude évalue l'association entre l'utilisation de faibles doses d'aspirine et le risque de développer la maladie
Background : A comprehensive body of evidence has shown that aspirin has cancer-preventive effects, particularly against gastrointestinal cancer, but its effects on the risk of ovarian cancer are less well established. This nationwide case-control study examined the association between low-dose aspirin and the risk of ovarian cancer. Patients and methods : We identified all patients in the Danish Cancer Registry aged 30–84 years old with a histologically verified first diagnosis of epithelial ovarian cancer during 2000–2011. Each patient was sex- and age-matched to 15 population controls using risk-set sampling. Prescription use, comorbidity, reproductive history and demographic characteristics data were obtained from nationwide registries. Use of low-dose (75–150 mg) aspirin was defined according to dose and duration and consistency of use. Conditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for the association between low-dose aspirin use and the risk of epithelial ovarian cancer, both overall and for specific histological types. Results : For 4,103 ovarian cancer cases and 58,706 population controls, the adjusted OR for epithelial ovarian cancer associated with ever use (≥2 prescriptions) of low-dose aspirin was 0.94 (95% CI: 0.85–1.05). ORs for epithelial ovarian cancer were lower with the use of 150 mg aspirin tablets (OR=0.82; 95% CI: 0.68–0.99) and with long-term use (≥5 years) of low-dose aspirin (OR=0.77; 95% CI: 0.55–1.08). Continuous long-term use of low-dose aspirin, defined as close consecutive prescriptions, was associated with a further reduction in OR (0.56; 95% CI: 0.32–0.97). For histological types of epithelial ovarian cancer, the strongest inverse associations with low-dose aspirin use were seen for mucinous and endometrioid tumours. Conclusion : This nationwide case-control study indicates that low-dose aspirin use may be associated with reduced risk of epithelial ovarian cancer.