Technological advances, biologic rationales, and the associated success of chemotherapy with hyperthermia in improved outcomes in patients with sarcoma
Mené sur 329 patients atteints d'un sarcome localisé des tissus mous à risque élevé de récidive (âge médian : 51 ans ; durée médiane de suivi : 11,3 ans), cet essai de phase III évalue, du point de vue de la survie sans progression locale, des taux de survie à 5 et 10 ans et de la sécurité, l'intérêt d'ajouter une hyperthermie régionale à une chimiothérapie néoadjuvante
Soft tissue sarcomas are a heterogeneous group of mesenchymal tumors that account for approximately 12 000 new cancer cases and almost 5000 deaths each year in the United States. For large (>5 cm), high-grade sarcomas of the extremity, surgical resection and radiation therapy can achieve local control in approximately 90% of patients.1,2 However, these patients are at risk for developing metastases to the lung. Therefore, in some sarcoma centers, patients with high-risk, localized sarcoma also receive chemotherapy. Even with systemic therapy, many patients die. Therefore, the European Organization for Research and Treatment of Cancer (EORTC) initiated a multinational, multi-institutional phase 3 randomized clinical trial (EORTC 62961-ESHO 95) to evaluate whether adding regional hyperthermia to chemotherapy improves outcomes for patients with localized high-risk soft tissue sarcoma.