The emerging roles of YAP and TAZ in cancer
Cet article passe en revue les travaux récents sur le rôle des protéines YAP et TAZ, liées à la voie de signalisation Hippo, dans la progression d'un cancer
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.