Salpingectomy as a Potential Ovarian Cancer Risk-Reducing Procedure
Menée à partir des données de registres médicaux suédois portant sur la période 1973-2009 (nombre de patientes : 251 465) et de données en population générale (nombre de personnes supérieur à 5 millions), cette étude évalue l'association entre le fait d'avoir subi une salpingectomie pour des indications bénignes et une réduction du risque de cancer de l'ovaire
Accumulated evidence over the past 10 years has strongly indicated that the fallopian tube is the site of origin for many high-grade serous carcinomas (1), which represent 50% to 60% of all epithelial ovarian cancers. This multi-origin model of ovarian cancer development has important implications for prevention of ovarian cancer: if some or all high-grade serous tumors develop in the fallopian tube, then bilateral salpingectomy could prevent this most aggressive form of ovarian cancer. However, to date, no large-scale data regarding the impact of salpingectomy on ovarian cancer incidence have been available. The article by Falconer et al. (2) is the first to address this question. This study combined data from several population registries in Sweden to compare incidence of ovarian cancer in women with a previous gynecologic procedure for benign indications (salpingectomy, tubal ligation, total abdominal hysterectomy with bilateral salpingo-oophorectomy [BSO], and hysterectomy without concomitant bilateral salpingo-oophorectomy [TAH]) to women with no history of these surgeries. They reported a statistically significant 35% lower risk of ovarian cancer among women with a previous salpingectomy compared with women with no previous surgeries. Consistent with previous studies, all other gynecologic surgeries evaluated in this study were associated with …
Journal of the National Cancer Institute , éditorial, 2015