Polymorphic CAG repeat and protein expression of androgen receptor gene in colorectal cancer
Menée sur 550 patients atteints d'un cancer colorectal et 540 témoins, cette étude évalue l'association entre la longueur d'une séquence répétant le motif CAG à l'intérieur du gène du récepteur des androgènes, le niveau d'expression de ce gène et la survie des patients
Although somatic alterations in CAG repeats in the androgen receptor (AR) gene have been suggested to predispose to colorectal cancer (CRC), less is known about AR in CRC carcinogenesis. Due to lack of relevant analysis on CAG repeat length and AR expression in CRC, we aimed to investigate the prognostic value of polymorphic CAG and protein expression of the AR gene in CRC patients. A case-control study was carried out on 550 CRC patients and 540 healthy controls to investigate whether polymorphic CAG within the AR gene is linked to increased risk for CRC. Polymorphic CAG and AR expression were analyzed to clarify their relationship with clinicopathological and prognostic factors in CRC patients. The study showed that the AR gene in CRC patients had a longer CAG repeat sequence than those in the control group, as well as increased risk for CRC among females (P = 0.013), males (P = 0.002), and total CRC population (P < 0.001), respectively. AR expression exhibited a significant difference in long CAG repeat sequence among males (P < 0.001), females (P < 0.001), and total CRC study population (P < 0.001). Both long CAG repeat sequence and negative AR expression were associated with a short 5-year overall survival (OS) rate in CRC. Long CAG repeat sequences and absence of AR expression were closely related to the development of CRC. Both long CAG and decreased AR expression were correlated with the poor 5-year OS in CRC patients.
http://mct.aacrjournals.org/content/early/2015/01/30/1535-7163.MCT-14-0620.abstract