Cancer Evolution Constrained by Mutation Order
A partir d'échantillons sanguins prélevés sur 246 patients atteints d'une néoplasie myéloproliférative présentant la mutation V617F du gène JAK2, cette étude met en évidence le rôle joué par l'ordre d'acquisition d'une mutation TAT2 (avant ou après la mutation JAK2) dans les caractéristiques cliniques de la maladie et la réponse à une thérapie ciblée
In Wonderful Life: The Burgess Shale and the Nature of History, Gould pondered the existence of species, focusing on biologic diversity in the Cambrian period more than 500 million years ago that led to the major body plans known today. He argued that the subsequent chapters of the evolutionary book of life were constrained by embedded developmental pathways. Evolution is dependent on antecedent steps that influence or constrain future evolutionary routes.
As analyses of the cancer genome deepen, parallels between ecological evolution and tumor evolution are apparent. These parallels suggest that the order of genetic events in tumors influences . . .
New England Journal of Medicine , éditorial, 2014