Gastrointestinal toxicities with combined anti-angiogenic and stereotactic body radiation therapy
Cet article décrit les différentes toxicités gastro-intestinales liées à un traitement combinant un médicament anti-angiogénique et une radiothérapie corporelle stéréotaxique, présente les mécanismes d'action associés à ces toxicités, puis identifie les futurs axes de recherche pour réduire les effets secondaires de ces traitements et permettre leur utilisation dans un contexte clinique plus large
Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with combined used of anti-angiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts.
http://www.redjournal.org/article/S0360-3016(15)00183-2/abstract