Metabolic pathways promoting cancer cell survival and growth
Cet article passe en revue les travaux récents sur les mécanismes par lesquels, en s'adaptant aux restrictions en nutriments à l'intérieur des tumeurs solides, les cellules malignes assurent leur survie
Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.