Carotenoid intakes from natural sources and head and neck cancer: a systematic review and meta-analysis of epidemiological studies
A partir d'une revue systématique de la littérature publiée jusqu'en mai 2014 (15 études incluant au total 5 482 cas et 14 130 témoins ; 1 étude comportant 34 691 femmes ménopausées), cette méta-analyse évalue l'association entre la consommation de caroténoïdes d'origine naturelle et le risque de cancer de la tête et du cou
Because of their role as antioxidants, the intake of carotenoids has been hypothesized to reduce the risk of head and neck cancer (HNC). We conducted a systematic review and meta-analysis of the epidemiological studies to investigate whether the intake of specific carotenoids from dietary sources, as well as combined carotenoids, is associated with the risk of HNC according to cancer subsites. A comprehensive literature search of Medline and Scopus databases was conducted. Sixteen articles were identified from the literature search, of which 15 case-control studies and one prospective cohort study. The risk reduction associated with β-carotene equivalents intake was 46% (95% CI: 20-63%) for cancer of oral cavity and 57% (95% CI: 23-76%) for laryngeal cancer. Lycopene and β-cryptoxanthin also reduced the risk for laryngeal cancer; the ORs for the highest category compared to the lowest one of carotenoid intake were 50% (95% CI: 11-72%) and 59% (95% CI: 49-67%), respectively. Lycopene, α-carotene, and β-cryptoxanthin were associated with at least 26% reduction in the rate of oral and pharyngeal cancer (95% CI: 2-44%). Our systematic-review and meta-analysis on dietary carotenoids intake and HNC showed carotenoids to act protectively against HNC, in relation to most of single-nutrients and subsites.