2,4-Dichlorophenoxyacetic Acid and Non-Hodgkin's Lymphoma, Gastric Cancer, and Prostate Cancer: Meta-analyses of the Published Literature
A partir d'une revue systématique de la littérature (14 études), cette méta-analyse fait le point sur l'association entre une exposition à de l'acide 2,4-dichlorophénoxyacétique (un désherbant) et le risque de lymphome non hodgkinien, de cancer de l'estomac ou de cancer de la prostate
Purpose : Despite evidence from experimental studies indicating that the herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), is not carcinogenic, several epidemiology studies have evaluated links between 2,4-D and cancer. Some suggest that 2,4-D is associated with non-Hodgkin's lymphoma (NHL), gastric cancer, and prostate cancer, but results have been inconsistent. We conducted meta-analyses to evaluate the weight of epidemiology evidence for these cancers. Methods : We identified articles from PubMed, Scopus, and TOXLINE databases and reference lists of review articles. We evaluated study quality and calculated summary risk estimates using random-effects models. We conducted subgroup and sensitivity analyses when possible. Results : We identified nine NHL, three gastric cancer, and two prostate cancer studies for inclusion in our meta-analyses. We found that 2,4-D was not associated with NHL (RR = 0.97, 95% CI = 0.77-1.22, I2 = 28.8%, pheterogeneity = 0.19) and this result was generally robust to subgroup and sensitivity analyses. 2,4-D was not associated with gastric (RR = 1.14, 95% CI = 0.62-2.10, I2=54.9%, pheterogeneity = 0.11) or prostate cancer (RR = 1.32, 95% CI = 0.37-4.69, I2 87.0%, pheterogeneity = 0.01). Conclusions : The epidemiology evidence does not support an association between 2,4-D and NHL, gastric cancer, or prostate cancer risk.