A randomised controlled trial to evaluate the efficacy of a 6-month dietary and physical activity intervention for patients receiving androgen deprivation therapy for prostate cancer
Mené au Royaume-Uni auprès de 94 patients atteints d'un cancer de la prostate et recevant une hormonothérapie anti-androgénique, cet essai randomisé analyse l'efficacité d'une intervention à base d'activité physique et d'un régime alimentaire durant 6 mois pour réduire les effets indésirables du traitement
Purpose : Treatment of prostate cancer with androgen deprivation therapy (ADT) is associated with an increased fat mass, decreased lean mass, increased fatigue and a reduction in quality of life (QoL). The aim of this study was to evaluate the efficacy of a 6-month dietary and physical activity intervention for prostate cancer patients receiving ADT, to help minimise these side effects. Methods : Patients (n = 94) were recruited to this study if they were planned to receive ADT for prostate cancer for at least 6 months. Men randomised to the intervention arm received a dietary and exercise intervention, commensurate with UK healthy eating and physical activity recommendations. The primary outcome of interest was body composition; secondary outcomes included fatigue, QoL, functional capacity, stress and dietary change. Results : The intervention group had a significant (p < 0.001) reduction in weight, body mass index and percentage fat mass compared to the control group at 6 months; the between-group differences were −3.3 kg (95 % confidence interval (95 % CI) −4.5, −2.1), −1.1 kg/m2 (95 % CI −1.5, −0.7) and −2.1 % (95 % CI −2.8, −1.4), respectively, after adjustment for baseline values. The intervention resulted in improvements in functional capacity (p < 0.001) and dietary intakes but did not significantly impact fatigue, QoL or stress scores at endpoint. Conclusions : A 6-month diet and physical activity intervention can minimise the adverse body composition changes associated with ADT. Implications for Cancer Survivors : This study shows that a pragmatic lifestyle intervention is feasible and can have a positive impact on health behaviours and other key outcomes in men with prostate cancer receiving ADT.