Urinary biomarkers for the detection and management of localized renal cell carcinoma
Menée à partir d'échantillons urinaires collectés auprès de 720 patients ayant subi une tomographie numérique abdominale de routine, 80 témoins sains et 19 patients atteints d'un carcinome rénal papillaire ou à cellules claires, cette étude évalue l'intérêt de mesurer le niveau de l'aquaporine-1 et de la périlipine-2 pour diagnostiquer un carcinome à cellules rénales
The incidence of renal masses is increasing because of the widespread use of abdominal imaging. As a result, urologists are often faced with a dilemma in the diagnostic and therapeutic approach to these masses, which are typically small (diameter <4 cm), asymptomatic, and often seen in patients with advanced age, comorbidities, or compromised renal function. Radiologic features can sometimes, but not always, differentiate benign from malignant tumors. Renal mass biopsy has recently been pursued more frequently with the hope of differentiating a benign or less aggressive mass, such as a chromophobe tumor or a low-grade clear cell tumor, from a malignant tumor.1 Indeed, there is a growing body of evidence supporting acceptable patient outcomes with active surveillance of such small renal masses (SRMs).2
JAMA Oncology , commentaire en libre accès, 2014