Prospective study of body fat distribution and the risk of endometrial cancer
A partir des données de la cohorte "Nurses’ Health Study" incluant 51 948 participantes, cette étude prospective évalue l'association entre le rapport tour de taille/tour de hanches, pondéré par l'indice de masse corporelle, et le risque de cancer du corps de l'utérus
Background : Epidemiologic studies have found that overall obesity is positively related to endometrial cancer (EC) risk. However, data assessing the association between body fat distribution and risk of EC are still limited. Methods : We followed 51,948 women who first reported waist circumference (WC) and hip circumference in 1986 in the Nurses’ Health Study. Waist-to-hip ratio (WHR) was calculated. Results : During 24 years of follow-up, 449 incident invasive EC cases were diagnosed. In a multivariate analysis without adjusting for body mass index (BMI), the relative risks (RRs) for EC comparing extreme categories were 2.44 (95% confidence interval [CI] 1.72–3.45) for WC and 1.69 (95% CI = 1.20–2.40) for WHR. However, after adjustment of BMI, those positive associations were substantially attenuated and no longer significant; RR = 1.08 (95% CI = 0.69–1.67) for WC and 1.15 (95% CI = 0.81–1.64) for WHR, respectively. Conclusion : In our prospective cohort study, we found no independent association between body fat distribution and the risk of EC after adjustment for BMI.