The Economics of Reproducibility in Preclinical Research
A partir d'une analyse de la littérature, cette étude évalue les coûts annuels induits par des travaux de recherche préclinique non reproductibles aux Etats-Unis
Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of irreproducible preclinical research exceeds 50%, resulting in approximately US$28,000,000,000 (US$28B)/year spent on preclinical research that is not reproducible—in the United States alone. We outline a framework for solutions and a plan for long-term improvements in reproducibility rates that will help to accelerate the discovery of life-saving therapies and cures.
PLoS Biology , article en libre accès, 2014