On the quantitative assessment of predictive biomarkers
Cette étude analyse les méthodes utilisées pour déterminer la sensibilité, la spécificité, la valeur prédictive positive ou négative des tests compagnons associés à des thérapies ciblées en oncologie
Predictive biomarkers are among the most direct steps towards converting precision medicine into a clinical reality. By their very definition they are fundamentally different from prognostic or diagnostic biomarkers – instead of helping identify individuals who will develop the disease, they focus on differentiating between those who will and will not “benefit” from treatment...
Journal of the National Cancer Institute , éditorial en libre accès, 2015