Sensitivity, Specificity, PPV, and NPV for Predictive Biomarkers
Cette étude analyse les méthodes utilisées pour déterminer la sensibilité, la spécificité, la valeur prédictive positive ou négative des tests compagnons associés à des thérapies ciblées en oncologie
Molecularly targeted cancer drugs are often developed with companion diagnostics that attempt to identify which patients will have better outcome on the new drug than the control regimen. Such predictive biomarkers are playing an increasingly important role in precision oncology. For diagnostic tests, sensitivity, specificity, positive predictive value, and negative predictive are usually used as performance measures. This paper discusses these indices for predictive biomarkers, provides methods for their calculation with survival or response endpoints, and describes assumptions involved in their use.
Journal of the National Cancer Institute , résumé, 2015