Cigarette Smoking and Risk of Pancreatic Cancer: A Clinic-Based Case-Control Study in the San Francisco Bay Area
Menée aux Etats-Unis auprès de 536 cas et 869 témoins, cette étude évalue l'association entre le tabagisme et le risque de cancer du pancréas
Purpose : Cigarette smoking is an established risk factor for pancreatic cancer (PC). We examined the association between cigarette smoking and PC in a San Francisco Bay Area (SFBA) clinic-based, case-control study. Methods : 536 cases and sex and age frequency-matched controls (N=869) were recruited predominately from the University of California San Francisco (UCSF) medical clinics between 2006 and 2011. Participants were interviewed in-person using structured questionnaires. Adjusted odds ratios (OR) were computed. Results : 48% of cases and controls reported never having smoked cigarettes; 39% of cases and 40% of controls were former smokers; 13% of cases and 12% of controls were current smokers. No association was found for either former (OR=0.85, 95% CI=0.66-1.1) or current cigarette smoking (men: OR=1.0, 95% CI=0.60-1.7; women: OR=1.2, 95% CI=0.73-2.1). No dose-response relationships were detected with number of cigarettes/day, smoking intensity, duration, or years-since-last-smoked. Comparisons with a 1995-1999 population-based UCSF study demonstrated a significantly increased proportion of never smokers in this study (P<.001). Conclusions : This study revealed no significant associations between cigarette smoking and PC in the SFBA during 2006-2011. Data suggest a reduction in the duration of smoking within the referral population.