IL-36gamma Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses
Menée in vitro et in vivo sur des modèles de mélanome et de cancer du poumon, cette étude met en évidence des mécanismes par lesquels la cytokine IL-36gamma favorise la réponse immunitaire antitumorale
Cytokines play a pivotal role in regulating tumor immunogenicity and antitumor immunity. IL-36gamma
is important for the IL-23/IL-17-dominated inflammation and anti-BCG Th1 immune responses. However, the impact of IL-36
gamma
on tumor immunity is unknown. Here we found that IL-36γ stimulated CD8+ T cells, NK cells, and γδ T cells synergistically with TCR signaling and/or IL-12. Importantly, IL-36γ exerted profound antitumor effects in vivo and transformed the tumor microenvironment in favor of tumor eradication. Furthermore, IL-36γ strongly increased the efficacy of tumor vaccination. Moreover, IL-36γ expression inversely correlated with the progression of human melanoma and lung cancer. Our study establishes a role of IL-36γ in promoting antitumor immune responses and suggests its potential clinical translation into cancer immunotherapy.