Development of Fibroblast Growth Factor Receptor Inhibitors: Kissing Frogs to Find a Prince?
Mené sur 65 patients atteints d'une tumeur solide de stade avancé, cet essai international de phase I évalue la toxicité et l'activité antitumorale d'un composé appelé JNJ-42756493, un inhibiteur de l'activité tyrosine kinase du récepteur FGFR
Fibroblast growth factor (FGF) and fibroblast growth factor receptor (FGFR) are important regulators of a variety of biologic functions, including cellular proliferation, differentiation, migration, angiogenesis, wound healing, and survival. The FGF protein family comprises 18 ligands that signal through four transmembrane tyrosine kinase receptors (FGFR1-4). A fifth receptor, FGFR5 (or FGFRL1), can bind FGF, but it lacks a tyrosine kinase domain...
Journal of Clinical Oncology , éditorial en libre accès, 2015