Development of a histone deacetylase 6 inhibitor and its biological effects
Menée à l'aide de modèle murins, cette étude évalue l'activité antitumorale d'un nouvel inhibiteur de l'histone désacétylase 6
We report the development of a potent, selective histone deacetylase 6 (HDAC6) inhibitor. This HDAC6 inhibitor blocks growth of normal and transformed cells but does not induce death of normal cells. The HDAC6 inhibitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing mice.