Adult weight gain and risk of prostate cancer: A dose–response meta-analysis of observational studies
A partir d'une revue systématique de la littérature publiée avant septembre 2014 (497 634 participants, 22 338 cas), cette méta-analyse évalue l'association entre une prise de poids à l'âge adulte et le risque de cancer de la prostate
The association between adult weight gain and risk of prostate cancer has not been widely studied and the findings are inconsistent. Therefore, our study aimed to investigate the association between adult weight gain and risk of prostate cancer. PubMed, Embase and Web of Science databases were searched for relevant studies published before September 2014 using terms related to weight gain and prostate cancer. Summary estimates were obtained using the random-effects model. Dose–response meta-analysis, sensitivity analysis and publication bias tests were performed. Nine studies involving 497,634 participants and 22,338 cancer cases were included. For total prostate cancer, a positive relationship with adult weight gain was observed until weight gain increased to >30 kg. For low-intermediate-risk prostate cancer, a positive relationship with adult weight gain was observed until weight gain increased to >15 kg. For high-risk prostate cancer, we observed a positive linear relationship with adult weight gain with a relative risk (RR) of 1.02 [95% confidence interval (CI) 1.00–1.04] for every 5-kg increase. For fatal prostate cancer, we observed a positive linear relationship with adult weight gain with an RR of 1.12 (95% CI: 1.05–1.19) for every 5-kg increase. There is evidence that adult weight gain is associated with an increased risk of high-risk and fatal prostate cancer, but only low weight gain is positively associated with low-intermediate-risk prostate cancer.