Mature answers but new questions in indolent and mantle-cell lymphoma
Mené sur 230 patients atteints d'un lymphome non hodgkinien indolent ou d'un lymphome à cellules du manteau réfractaire ou récidivant, cet essai randomisé multicentrique de phase III compare l'efficacité, du point de vue de la survie dans progression, et la toxicité de la bendamustine et de la fludarabine en combinaison avec le rituximab
Impressive advances in understanding of lymphoma biology, and therapeutic advances that increase survival have occurred in the past decade. Indolent lymphomas encompassing several subtypes are often grouped together in clinical trials, although as specific molecular drivers are identified this is no longer tenable, at least for targeted therapies. Mantle-cell lymphoma is a distinct entity that is grouped with indolent lymphomas in some studies—as both are incurable with standard treatments—but mantle-cell lymphoma has a more rapid disease course than indolent lymphomas.
The Lancet Oncology , commentaire, 2014