Mortality, Cancer Incidence and Survival in Parents Following Bereavement
Menée en Israël auprès de 2 828 mères et 2 532 pères ayant perdu un enfant et auprès de 74 645 témoins, cette étude évalue l'association entre le fait de perdre un enfant, le risque de cancer et la mortalité spécifique chez les parents (durée moyenne de suivi pour l'incidence de cancer : 35,6 ans ; durée moyenne de suivi pour la mortalité : 39,1 ans)
Background : The study objective was to investigate whether child-loss is related to mortality, cancer incidence and cancer survival in parents. Methods : We utilized a population-based birth cohort (1964-1976) in Jerusalem and ascertained mortality (average follow-up of 39.1 years) and any cancer (average follow-up of 35.6 years) among parents who lost a child (2,838 mothers and 2,532 fathers) and among non-bereaved parents (38,212 mothers and 36,433 fathers). We also assessed mortality among parents with cancer. Time-dependent Cox models were used to estimate hazard ratios (HRs) with 95% CIs. Results : Overall mortality rates among bereaved parents were modestly increased when compared to non-bereaved parents (HR=1.18, 95%CI 1.05-1.32 in mothers; HR=1.10, 95%CI 1.01-1.20 in fathers). Hazard models indicated a significant relationship between bereavement and deaths from CHD in mothers (HR=1.90, 95%CI 1.23-2.95) and circulatory causes in both parents (HR=1.69; 95%CI 1.22-2.34 in mothers and HR=1.25; 95%CI 1.02-1.54 in fathers). Bereavement was not associated with parental risk of cancer disease and with survival from cancer. The association between bereavement and parental overall mortality were similar in the different parental socio-demographic characteristics. We observed a decrease in HRs for parental mortality associated with bereavement, with increasing time since the death of the child (HRs=9-10, 0-3 years; HRs=0.9-1.0, 9+ years; p heterogeneity ≤3x10-32). A similar decrease in HRs was observed for parental survival from cancer (HRs=6.7-8.7, 0-3 years; HRs=0.9-1.0, 9+ years). Conclusions : Our study suggests that child-loss was associated with slightly increased risk of all-cause and circulatory mortality in parents but not with incidence of cancer and cancer survival. The considerable increased parental mortality during a short period after child-loss support the involvement of pathways related to psychological stress.