Prognostic Subgroups among Patients with Stage II Colon Cancer
Menée à l'aide d'une nouvelle approche bio-informatique et sur 466 patients atteints d'un cancer du côlon de stade II ou III, puis validée sur 314 patients complémentaires, cette étude évalue l'association entre l'expression tumorale de CDX2 et le bénéfice, en termes de survie sans maladie à 5 ans, d'une chimiothérapie adjuvante
Colon cancer has traditionally been treated surgically. However, many cases of colon cancer are systemic at the time of diagnosis, and apparently curative surgery is followed at a later date by tumor recurrence as a consequence of circulating tumor cells before the surgery. Adjuvant medical therapies are designed to prevent recurrences after surgical resection.
New England Journal of Medicine , éditorial en libre accès, 2015