Role of radiation therapy in melanomas: systematic review and best practice in 2015
A partir d'une revue systématique de la littérature publiée entre 1976 et 2015 (99 articles), cette étude analyse les indications de la radiothérapie dans le traitement de divers types de mélanome, puis présente des recommandations
Radiotherapy has been used for skin cancers since early after the discovery of x-rays. The introduction of sophisticated surgery techniques and information of the general population on potential late radiation-induced toxicity and carcinogenesis have led to limiting indications in the dermatologist community. However, radiotherapy has undergone considerable developments, essentially including technological advances, to sculpt radiation delivery, with demonstration of the benefit either alone or after adding concomitant cytotoxic agents or targeted therapies. Although side effects due to high doses and/or the use of old RT techniques have been significantly decreased, the risk of atrophic scars, ulcerations or secondary cancers persist. In this systematic review, we aim to discuss indications for radiotherapy in melanomas with focus on new advances that may lead to rehabilitating this treatment option according to the tumor radiosensitivity and clinical benefit/risk ratio. Melanomas have been considered as radioresistant tumors for many years.
http://www.sciencedirect.com/science/article/pii/S1040842816300166