Extent of resection in medulloblastoma : time to reconsider ?
Menée à partir de données portant sur 787 patients atteints d'un médulloblastome, cette étude multicentrique évalue, en fonction du type moléculaire de la tumeur, l'effet de l'étendue de la résection sur la survie sans progression et la survie globale des patients
Medulloblastoma is the most common malignant brain tumour of childhood and is treated by use of a multimodal approach with surgery, radiotherapy, and chemotherapy. Risk stratification based on prognostic variables has been used to define average and high-risk groups of patients and to assign treatment accordingly. Initially, risk stratification was mainly based on clinical prognostic factors such as age, presence of metastases, and the extent of tumour resection, but more recently, with the rapid increase in knowledge of the molecular pathology of medulloblastoma, refinements to risk stratification have been proposed that combine clinical, pathological, and molecular data.
The Lancet Oncology , commentaire, 2015