Chemotherapy risks to fertility of childhood cancer survivors
A partir des données de la cohorte "Childhood Cancer Survivor Study" incluant 10 938 cas et 3 949 témoins, cette étude analyse les effets des chimiothérapies sur les capacités reproductrices de patients ayant survécu à un cancer durant l'enfance entre 1970 et 1999 (durée médiane de suivi : 8 ans)
The adverse effects of some cancer treatments on male and female fertility are well established, and have led to the development of a new specialty of medicine, bridging oncology and reproductive medicine.1 The US Childhood Cancer Survivor Study (CCSS) has provided benchmark studies reporting the effect of cancer treatment on reproductive outcomes in survivors of childhood cancer.2,3 Recognition of the adverse effects of radiotherapy has led to the development of protocols reducing or eliminating radiotherapy, and there is growing reliance on regimens of chemotherapy alone.
The Lancet Oncology , commentaire, 2015