Complete lymph node dissection in melanoma
Mené sur 483 patients atteints d'un mélanome avec envahissement du ganglion sentinelle, cet essai multicentrique de phase III évalue l'efficacité, du point de vue de la survie sans métastase distante, et les effets indésirables d'une lymphadénectomie radicale
Historically, surgeons removed the draining lymph node basin with the resection of the primary melanoma in an attempt to control local-regional disease and perhaps reduce recurrence and improve survival. With the advent of sentinel lymph node biopsy, a complete lymph node dissection has only been done in those patients with a positive sentinel lymph node biopsy, a known poor prognostic factor. However, only 20% of patients undergoing a complete lymph node dissection after a positive sentinel lymph node biopsy have additional disease detected.
The Lancet Oncology , commentaire, 2015