Long-Term Particulate Matter Exposures During Adulthood and Risk of Breast Cancer Incidence in the Nurses' Health Study II Prospective Cohort
A partir des données de la cohorte "Nurses' Health Study II" incluant 115 921 participantes, cette étude de cohorte prospective évalue l'association entre une exposition à une pollution atmosphérique issue du trafic routier et le risque de cancer du sein (3 416 cas)
Background: There is increasing concern that environmental exposures, such as air pollution, may be related to increasing rates of breast cancer; however, results from cohort studies have been mixed. We examined the association between particulate matter and measures of distance to roadway with the risk of incident breast cancer in the prospective nationwide Nurses' Health Study II (NHSII) cohort. Methods: Incident invasive breast cancer 1993-2011 (N=3,416) was assessed among 115,921 women in the NHSII cohort. Time-varying Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95%CIs) for increases in ambient exposures to PM10, PM2.5-10, and PM2.5 and residential roadway proximity categories. Results: In multivariable adjusted models, there was little evidence of an increased risk of breast cancer (or any of the receptor-specific subtypes) overall or by menopausal status with PM exposure. There was, however, a suggestion of increased risks among women living <50m of the largest road type (HR of 1.60 (95%CI: 0.80-3.21)) or within <50m of the two largest road types (1.14 (95%CI: 0.84-1.54)) compared to women living farther ({greater than or equal to}200m) away. Conclusions: Among women in the NHSII, we found no statistically significant associations between particulate matter exposures and incidence of breast cancer overall, by menopausal status, or by hormone receptor subtype. There was, however, a suggestion that residential proximity to major roadways may be associated with increased risk. Impact: These results suggest no elevated breast cancer risk with increasing exposures to particulate matter air pollution, but that other traffic-related exposures may be important.