Blood-based screening for colon cancer: A disruptive innovation or simply a disruption?
Ce dossier présente un ensemble d'articles sur le dépistage du cancer colorectal ainsi qu'une mise à jour des recommandations de l'"US Preventive Services Task Force"
On April 13, 2016, the US Food and Drug Administration (FDA) approved the first blood-based screening test for colon cancer. The assay (Epi proColon) relies on qualitative detection of the methylated septin 9 gene (SEPT9) and has been considered an innovation in screening. Despite multiple accepted options for colorectal cancer screening—including stool-based tests, such as the fecal occult blood test (FOBT) and lower endoscopy—handling, storing, and returning stool tests or prepping and undergoing an invasive procedure have limited adherence. Approximately one-fourth of eligible individuals aged 50 to 75 years have never been screened for colon cancer, and half are inadequately screened. Blood-based cancer screening has the potential to address this gap. Yet physicians must question how this newly approved assay might be incorporated in routine clinical practice, and, most important, whether use of the test will reduce colorectal cancer mortality.
JAMA , article en libre accès, 2015