Economic sustainability of anti-PD-1 agents nivolumab and pembrolizumab in cancer patients: Recent insights and future challenges
Cette étude italienne analyse le rapport coût-efficacité des immunothérapies à base de nivolumab et de pembrolizumab pour prendre en charge les patients atteints d'un mélanome de stade avancé, d'un cancer du poumon non à petites cellules ou d'un carcinome à cellules rénales
Highlights •Immunotherapy has emerged as a new approach to treat cancer patients. •Nivolumab and pembrolizumab have received approval for melanoma, NSCLC and RCC. •Despite their enthusiastic results, their high costs suggest careful consideration. •The cooperation between clinicians and economists will be crucial in future years. •This will guarantee economic sustainability and access to care for all patients. Abstract Anti-programmed death (PD)-1 agents pembrolizumab and nivolumab have recently obtained enthusiastic results in terms of progression-free survival (PFS), overall survival (OS) and tolerability in cancer patients. Despite these promising data, the high cost of these agents needs careful consideration. Indeed, the evaluation of cost-effectiveness analysis (CEA) and quality-adjusted life year (QALY), as well as different drug reimbursement modalities, will represent fundamental tools in order to guarantee the economic sustainability of health system and the access to care for all cancer patients. In this review, we discussed the recent results obtained by immunotherapy in cancer patients and we evaluated the economic impact of recently approved nivolumab and pembrolizumab in patients with advanced melanoma, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC).