Cancer of unknown primary: time to put the pieces of the puzzle together?
Menée initialement sur un ensemble de 10 481 échantillons tumoraux prélevés sur des patients atteints d'un cancer de localisation connue, puis sur 216 échantillons prélevés sur des patients atteints d'un cancer d'origine primitive inconnue, cette étude évalue les performances d'un outil de classification, basé sur un profil de méthylation de l'ADN, pour identifier la localisation de la tumeur primitive
About 3–5% of all human cancers manifest as cancer of unknown primary. Standard imaging work-up and meticulous pathological evaluation are the initial steps in the diagnostic algorithm of a presumed cancer of unknown primary. In recent decades, post-mortem discovery of occult primaries in a high proportion of patients has provided evidence that cancer of unknown primary represents a heterogeneous group of malignancies that share the characteristic of having a primary site that is undetectable with current methods.
The Lancet Oncology , commentaire, 2015