Cancer in patients with inherited ciliopathies: polycystic kidney disease
Menée à Taïwan à partir de données portant sur 4 346 patients atteints d'une polykystose rénale et sur 4 346 témoins (durée médiane de suivi : 3,72 ans), cette étude de cohorte évalue l'association entre la maladie et le risque de cancer (foie, côlon, rein)
It is well established that cancer occurs more frequently than expected in immunosuppressed patients after organ transplantation, in patients with advanced-stage kidney disease who are on dialysis, and in those with a mild to moderate reduction in renal function.1,2 In patients with decreased renal function, the increased risk seems to be cancer site-specific, with trends towards increased risks of urinary tract and colorectal cancers identified.3 However, no established evidence is available to suggest that the primary cause of end-stage kidney disease or renal dysfunction has an independent effect on the increased risk of cancer.
The Lancet Oncology , commentaire, 2015