The impact of receiving predictive genetic information about Lynch syndrome on individual colonoscopy and smoking behaviours
Menée en Australie, cette étude en population analyse les effets des résultats de tests génétiques de susceptibilité au syndrome de Lynch sur les changements de comportements de santé, notamment en matière de recours à des coloscopies ou de cessation du tagagisme pour prévenir le cancer colorectal
Background:This study investigated whether receiving the results of predictive genetic testing for Lynch syndrome-indicating the presence or absence of an inherited predisposition to various cancers, including colorectal cancer (CRC)-was associated with change in individual colonoscopy and smoking behaviours, which could prevent CRC. Methods:The study population included individuals with no previous diagnosis of CRC, whose families had already-identified deleterious mutations in the MMR or EPCAM genes. Hypotheses were generated from a simple health economics model and tested against individual-level panel data from the Australasian Colorectal Cancer Family Registry. Results:The empirical analysis revealed evidence consistent with some of the hypotheses, with a higher likelihood of undergoing colonoscopy in those who discovered their genetic predisposition to CRC and a lower likelihood of quitting smoking in those who discovered their lack thereof. Conclusions:Predictive genetic information about Lynch syndrome was associated with change in individual colonoscopy and smoking behaviours but not necessarily in ways to improve population health. Impact:The study findings suggest that the impact of personalized medicine on disease prevention is intricate, warranting further analyses to determine the net benefits and costs.