Dairy, calcium, vitamin D and ovarian cancer risk in African-American women
Menée sur 490 patientes afro-américaines atteintes d'un cancer de l'ovaire et sur 656 témoins, cette étude évalue l'association entre la consommation de produits laitiers, de calcium ou de vitamine D et le risque de développer la maladie
Background : No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African–American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency. Methods : We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African–American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results : An increased ovarian cancer risk was observed for whole milk consumption and lactose intake (highest quartile vs lowest: OR=1.97, 95% CI: 1.25–3.10;P-trend: 0.008). Calcium intake was associated with a decreased risk of ovarian cancer (OR=0.51, 95 CI%: 0.30–0.86; P-trend: 0.009), but vitamin D intake was not. Longer sun exposure in summer months was found to predict a lower risk (OR=0.71, 95% CI: 0.51–0.99; P-trend: 0.049). Conclusions : Our findings suggest that a high-calcium, low-lactose diet, and sun exposure in summer months may reduce the risk of ovarian cancer in African–American women.