The association between alcohol consumption and breast density: a systematic review and meta-analysis
A partir d'une revue systématique de la littérature (20 études), cette méta-analyse évalue l'association entre une consommation d'alcool, la densité mammaire et le risque de cancer du sein
Background:Percent breast density (PBD) is a strong risk factor for breast cancer that is influenced by several other risk factors for the disease. Alcohol consumption is associated with an increased risk of breast cancer with an uncertain association with PBD. We have carried out a systematic review and meta-analysis to examine the association of alcohol consumption with PBD. Methods:We searched nine databases to identify all relevant studies on the association between alcohol intake and breast density. Two independent investigators evaluated and selected 20 studies that were included in our analyses. We divided the studies into 3 groups according to the methods used to measure and analyze the association of BD with alcohol consumption. Results:Meta-analysis of the 11 studies that used quantitative methods to measure and analyse PBD as a continuous variable found a statistically significant difference in PBD when comparing the highest to the lowest alcohol level (β = 0.84, 95% CI 0.12, 1.56). Three studies that used quantitative methods to measure PBD and categories of PBD for analysis had a summary odds ratio = 1.81 (95% CI: 1.07, 3.04). Five studies that used categories to classify PBD and analyse their association with alcohol intake had a summary odds ratio=1.78 (95% CI: 0.90, 3.51). Conclusions:These results suggest that there is a positive association between alcohol intake and PBD. Impact. Alcohol may increase the risk of breast cancer associated with PMB.%U http://cebp.aacrjournals.org/content/cebp/early/2016/09/24/1055-9965.EPI-16-0522.full.pdf