The multifaceted roles of fatty acid synthesis in cancer
Cet article passe en revue les travaux récents sur des mécanismes par lesquels le métabolisme lipidique, notamment la synthèse des acides gras, favorise le développement et la progression d'une tumeur
Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular process that converts nutrients into metabolic intermediates for membrane biosynthesis, energy storage and the generation of signalling molecules. This Review explores how different aspects of FA synthesis promote tumorigenesis and tumour progression. FA synthesis has received substantial attention as a potential target for cancer therapy, but strategies to target this process have not yet translated into clinical practice. Furthermore, efforts to target this pathway must consider the influence of the tumour microenvironment.