Associations of post-diagnosis physical activity and change from pre-diagnosis physical activity with quality of life in prostate cancer survivors
Menée au Canada auprès de 830 patients ayant survécu à un cancer de la prostate, cette étude prospective évalue l'association entre l'évolution de leur activité physique de loisirs, avant et après le diagnostic, et leur qualité de vie
Background: This prospective study examined the associations between post-diagnosis physical activity and change from pre-diagnosis physical activity with quality of life (QoL) in prostate cancer survivors. Methods: Prostate cancer survivors (n=830) who participated in a case-control study with invasive stage {greater than or equal to}II disease were followed up to 2007 to capture QoL outcomes. At baseline and three time points post-diagnosis (2000-2007), interviews/questionnaires were used to collect data on physical activity, general QoL measured by the SF-36 and other treatment/lifestyle factors. Multivariable linear regression was used to test the relation between post-diagnosis physical activity and QoL as well as the change in physical activity over the diagnostic period and QoL. Results: Both total and recreational physical activities were positively associated with physical QoL. Further, when comparing changes in physical activity levels from pre- to post-diagnosis, men who consistently met physical activity guidelines had significantly higher physical (β = 6.01, 95% CI, 4.15-7.86) and mental (β = 2.32, 95% CI, 0.29-4.34) QoL scores compared to those who did not meet guidelines pre- or post-diagnosis. Further, those who adopted and met guidelines had increased QoL, while those who relapsed experienced decreased QoL. Conclusions: Post-diagnosis recreational physical activity is associated with better physical QoL in prostate cancer survivors. Moreover, prostate cancer survivors who maintain or adopt physical activity after diagnosis report substantially higher QoL than men who never exercised or stopped exercising after diagnosis. Impact: Future intervention studies should focus on achieving and maintaining adherence to physical activity guidelines post-diagnosis in prostate cancer survivors.%U http://cebp.aacrjournals.org/content/cebp/early/2016/09/27/1055-9965.EPI-16-0465.full.pdf