Long-term results of fertility-sparing treatment compared with standard radical surgery for early-stage epithelial ovarian cancer
Menée à partir de données portant sur 1 031 patientes atteintes d'un cancer de l'ovaire de stade précoce (durée médiane de suivi : 11,9 ans), cette étude évalue, du point de vue du risque de récidive et de la survie spécifique, la sécurité d'un traitement chirurgical préservant la fertilité par rapport à un traitement chirurgical radical
Background : The objective of this study is to evaluate the safety of fertility-sparing surgery (FSS) for early-stage epithelial ovarian cancer (EOC). Methods : A retrospective analysis was performed to identify patients treated for early-stage EOC and to compare the clinical outcomes of patients treated with FSS and radical surgery (RS). Results : A total of 1031 patients were treated at two Institutions, 242 with FSS (group A) and 789 with RS (group B). Median duration of follow-up was 11.9 years. At univariate analyses, FSS was associated with decreased risk of relapse (P=0.002) and of tumour-related death (P=0.001). Multivariate analysis did not confirm the independent positive role of FSS neither on relapse-free interval (RFI) nor on cancer-specific survival (CSS). Tumour grade was associated with shorter RFI (P<0.001) and shorter CSS (P=0.001). The type of treatment did not influence CSS or RFI in any grade group. We also found a significant association between low-grade tumours and younger age. Conclusions : Fertility-sparing surgery is an adequate treatment for patients with stage I EOC. The clinical outcome of patients with G3 tumours, which is confirmed to be the most important prognostic factor, is not determined by the type of treatment received.