How tobacco smoke changes the (epi)genome
A partir de 5 243 échantillons tumoraux prélevés sur des patients atteints d'un cancer lié au tabagisme, cette étude identifie des signatures mutationnelles associées à différentes localisations cancéreuses, selon que le tissu concerné est exposé directement ou indirectement à la fumée de tabac
Worldwide, more than 1 billion people are tobacco smokers. Cigarette smoking drastically increases the risk of lung cancer. However, many other cancer types also occur more frequently in smokers than in nonsmokers, including cancers of the oral cavity, larynx, pharynx, esophagus, liver, cervix, pancreas, bladder, and kidney. Genome sequencing efforts are beginning to provide more sophisticated clues as to the processes at work that are shaping the mutational landscape of tumors. On page 618 of this issue, Alexandrov et al. (1) focused specifically on smokingassociated cancers and dissected genetic and epigenetic differences in tumors between smokers and lifetime nonsmokers.
Science , commentaire, 2015